Patient with Lumbar Spondylosis and Diskogenic Pain
- Studies suggest that early and gradual physical and behavioral therapies in combination with pharmacologic therapies should be encouraged in all patients as the initial treatment for patients with diskogenic low back pain (LBP).
- Recent studies have found an association between microbial infection and symptomatic disk degeneration. Low-virulence microorganisms, in particular Propionibacterium acnes, might be causing a chronic low-grade infection in the lower intervertebral disks. A subset of patients with Modic type I changes in magnetic resonance imaging may benefit antibiotic therapy directed at the infected disks by P. acnes and other low-virulence microorganisms.
- There is accumulating evidence to support several interventional therapies for chronic diskogenic LBP. Biacuplasty is supported by level Ib evidence. Epidural steroid injection and gray ramus communicans radiofrequency ablation are supported by level II evidence. Intradiskal injections with methylene blue, ozone, or steroid have variable levels of evidence.
- Regenerative strategies using cell-based therapies have shown promise to provide equal or even better outcomes compared with surgical spinal fusion or total disk replacement with an artificial disk.








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