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Evaluation and Treatment of Monogenic Forms of Inflammatory Bowel Diseases 

    • Advanced genetic platforms have identified more than 50 different monogenic disorders causing inflammatory bowel disease.
    • A monogenic cause of inflammatory bowel disease should be suspected in patients with atypical or severe IBD phenotypes.
    • The diagnosis of monogenic defects is made through a combination of functional immunologic studies and DNA sequencing (whole exome sequencing).
    • Monogenic IBDs usually present in the first years of life, but several diseases manifest adolescence or adulthood.
    • Identifying a monogenic form of inflammatory bowel disease can lead to tailored specific therapy (eg, stem cell transplantation) and have major impact on patient’s care.

Evaluation and Treatment of Monogenic Forms of Inflammatory Bowel Diseases 

    • Advanced genetic platforms have identified more than 50 different monogenic disorders causing inflammatory bowel disease.
    • A monogenic cause of inflammatory bowel disease should be suspected in patients with atypical or severe IBD phenotypes.
    • The diagnosis of monogenic defects is made through a combination of functional immunologic studies and DNA sequencing (whole exome sequencing).
    • Monogenic IBDs usually present in the first years of life, but several diseases manifest adolescence or adulthood.
    • Identifying a monogenic form of inflammatory bowel disease can lead to tailored specific therapy (eg, stem cell transplantation) and have major impact on patient’s care.

Evaluation and Treatment of Monogenic Forms of Inflammatory Bowel Diseases 

    • Advanced genetic platforms have identified more than 50 different monogenic disorders causing inflammatory bowel disease.
    • A monogenic cause of inflammatory bowel disease should be suspected in patients with atypical or severe IBD phenotypes.
    • The diagnosis of monogenic defects is made through a combination of functional immunologic studies and DNA sequencing (whole exome sequencing).
    • Monogenic IBDs usually present in the first years of life, but several diseases manifest adolescence or adulthood.
    • Identifying a monogenic form of inflammatory bowel disease can lead to tailored specific therapy (eg, stem cell transplantation) and have major impact on patient’s care.

Systemic Lupus Erythematosus

    • A 2018 Rheumatology guideline for the management of adult systemic lupus erythematosus
    • A 2015 Diagnosis, Monitoring, and Treatment of Systemic Lupus Erythematosus: A Systematic Review of Clinical Practice Guidelines. Arthritis Care and Research

Systemic Lupus Erythematosus

    • A 2018 Rheumatology guideline for the management of adult systemic lupus erythematosus
    • A 2015 Diagnosis, Monitoring, and Treatment of Systemic Lupus Erythematosus: A Systematic Review of Clinical Practice Guidelines. Arthritis Care and Research

Hemorrhoids

    • Rubber band ligation remains the most effective nonexcisional technique available.
    • Advanced energy devices such as the LigaSure technique and Harmonic scalpel have demonstrated a modest decrease in immediate postoperative pain with equal efficacy when compared to the traditional excisional hemorrhoidectomy, however at a greater cost.
    • At this time, stapled hemorrhoidopexy and Doppler-guided hemorrhoidal dearterialization have not been shown to have a clear advantage over the traditional excisional hemorrhoidectomy.

Management of Neuroendocrine Tumors of the Pancreas

    • A multidisciplinary experienced team optimizes the management of pancreatic neuroendocrine tumors.
    • All patients should have a careful clinical review before treatment decisions are finalized.
    • The range of treatment options described in this report should be considered at each clinical decision point.

Management of Neuroendocrine Tumors of the Pancreas

    • A multidisciplinary experienced team optimizes the management of pancreatic neuroendocrine tumors.
    • All patients should have a careful clinical review before treatment decisions are finalized.
    • The range of treatment options described in this report should be considered at each clinical decision point.
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