Latest Updates

Pelvic Organ Prolapse IV: Surgical Options

    • Minimally invasive approaches to traditional open abdominal sacrocolpopexy result in decreased patient morbidity and faster recovery while providing similar anatomic and subjective outcomes
    • Uterine-sparing hysteropexy procedures eliminate complications attributed to hysterectomy at the time of prolapse repair while providing similar anatomic and subjective outcomes
    • Numerous native tissue repair techniques allow for prolapse repair without the use of synthetic graft material

Clinical Management of Drug Use Disorders

    • Outlines updated DSM-5 classifications of substance use disorders
    • Synthesizes current heritable and genetic factors in substance use disorders
    • Reviews current treatment options with the strongest evidence base
    • Updated with 2020 ASAM Practice Guidelines: Opioid Use Disorder

Neurobiology of Addiction

    • Epidemiology of and heritable risk factors for developing addictive disorders
    • Dysregulated brain networks and neurochemical systems in several substance and nonsubstance addictions
    • Treatment options for substance and nonsubstance addictions
    • Updated with 2020 ASAM Practice Guidelines: Opioid Use Disorders

Clinical Management of Drug Use Disorders

    • Outlines updated DSM-5 classifications of substance use disorders
    • Synthesizes current heritable and genetic factors in substance use disorders
    • Reviews current treatment options with the strongest evidence base
    • Updated with 2020 ASAM Practice Guidelines: Opioid Use Disorder

Clinical Management of Drug Use Disorders

    • Outlines updated DSM-5 classifications of substance use disorders
    • Synthesizes current heritable and genetic factors in substance use disorders
    • Reviews current treatment options with the strongest evidence base
    • Updated with 2020 ASAM Practice Guidelines: Opioid Use Disorder

Constipation: Diagnosis and Management

    • Updated with 2019 CAG Practice Guidelines for IBS
    • Added 2016 ASCRS Practice Guidelines for Constipation

Clinical Trial Design and Statistics

    • Because of the complex nature of clinical trial design, significant resources and infrastructure are invested in drug development. Many drugs fail to progress beyond the phase I/II stage, and many phase III trials take years to accrue and publish results, leading to a delay in Food and Drug Administration (FDA) approval for diseases that desperately need better therapeutic options.
    • The relatively recent FDA Safety and Innovation Act has allowed for the creation of priority and expedited review for drugs and biologics in serious conditions and where there is an unmet medical need.
    • The designation of fast-track or breakthrough therapy may be granted when there is preclinical or clinical evidence to suggest that the intervention may result in a substantial improvement over currently available therapies.`

Drugs of Abuse

    • In the last decade, dozens of novel agents of abuse have emerged, many of them chemical variants of the naturally occurring cathinone found in the plant Catha edulis. 
    • Synthetic cathinones may be sold under the name of bath salts or plant food to subvert legal restrictions on their use. Their beta-ketone amphetamine structure results in their amphetamine-like sympathomimetic effects. However, synthetic cathinones also seem to modulate serotonin release, resulting in various psychoactive effects.
    • Toxicity in patients using synthetic cathinones varies from euphoria and intoxication, to florid violent hallucinations, hyperthermia, rhabdomyolysis, seizures, and death. Unlike many other street drugs, synthetic cathinones are often known more commonly by their street name (e.g., bath salts), with the exact chemical composition changing over time in response to legal pressures. 
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