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Behavior Modification In The Treatment Of Obesity

    • Weight loss interventions are most successful when they involve an integrated approach including behavioral, dietary, and exercise components. The more often a patient is seen, the better the results.
    • In primary care practice, the 5As model of intervention, including the Assess, Advise, Agree, Assist, and Arrange steps, has been empirically validated and recommended as effective in treating overweight and obesity.
    • Both the comprehensiveness of behavioral skills and the quantity of treatment sessions are linked to improved outcomes.
    • Individualized plans and participation in small-group treatment have been shown to lead to greater success with weight loss.
    • Patients who demonstrate greater internal motivation, self-efficacy, and ability to regulate their eating tend to be more successful with weight loss and exercise within the first year.

Herpesvirus Infections

    Extracorporeal Membrane Oxygenation

      • Extracorporeal membrane oxygenation (ECMO) is an advanced form of life support that has undergone explosive growth in its use over the past decade.
      • Advancement in the design of the circuit oxygenator has been the major technological improvement in ECMO. This has allowed for longer durations of support without damaging the red blood cells.
      • The indications for ECMO continue to expand with active growth in ECMO as a bridge to heart and lung transplantation and left ventricular assist device placement for refractory heart failure and as a rescue modality during cardiopulmonary resuscitation.
      • Continued research is needed to standardize ECMO practices and protocols to improve survival.

    Endoscopic Correction of Vesicoureteral Reflux

      • The appropriate endpoint of endoscopic correction of vesicoureteral reflux is elimination of hydrodistension and at least 1 mL bulking substance per ureter
      • The double hydrodistension implantation technique is the most effective method of endoscopic injection  
      • The timing of vesicoureteral reflux is the most important factor in predicting spontaneous reflux resolution 

    New Endoscopic Techniques

      • Endoscopic techniques such as endoscopic mucosal resection and endoscopic submucosal dissection allow for resection of superficial mucosal neoplasms throughout the gastrointestinal tract.
      • Multimodality endoscopic eradication therapy involves combining endoscopic mucosal resection and radiofrequency ablation to achieve complete eradication of Barrett esophagus.
      • Peroral endoscopic myotomy has been developed as a minimally invasive endoscopic alternative to Heller myotomy in the treatment of achalasia.
      • Novel endoscopic techniques allow for drainage of pseudocysts and walled-off pancreatic necrosis and create connections between luminal gastrointestinal structures.
      • Novel endoscopic techniques exist in both primary management of patients with obesity and management of complications of bariatric surgery.

    New Endoscopic Techniques 

      • Endoscopic techniques such as endoscopic mucosal resection and endoscopic submucosal dissection allow for resection of superficial mucosal neoplasms throughout the gastrointestinal tract.
      • Multimodality endoscopic eradication therapy involves combining endoscopic mucosal resection and radiofrequency ablation to achieve complete eradication of Barrett esophagus.
      • Peroral endoscopic myotomy has been developed as a minimally invasive endoscopic alternative to Heller myotomy in the treatment of achalasia.
      • Novel endoscopic techniques allow for drainage of pseudocysts and walled-off pancreatic necrosis and create connections between luminal gastrointestinal structures.
      • Novel endoscopic techniques exist in both primary management of patients with obesity and management of complications of bariatric surgery.

    Medical Management Of Pulmonary Embolism

      • Description of current guidelines for the management of high-risk (“massive”), medium-risk (“submassive”), and low-risk pulmonary embolism
      • Detailed discussion of anticoagulants available in the United States including the newer direct oral anticoagulants
      • Review of indications for catheter-based interventions and inferior vena cava filter placement

    Management of Small Renal Masses

      • An improved understanding of the natural history of SRMs underscores their overall slow growth rate and low propensity to metastasize.
      • Up to 30% of SRMs are benign, highlighting a role for upfront renal tumor biopsy to stratify those patients requiring therapy. Contemporary experience has demonstrated the safety in performing renal tumor biopsy and the excellent diagnostic rates (> 90%) that can be achieved at centers of excellence. 
      • There is an increasing role for active surveillance for SRMs, with appropriately selected patients achieving excellent clinical outcomes.
      • Partial nephrectomy remains the gold standard treatment for SRMs requiring intervention when technically feasible.
      • The management of SRMs is evolving towards a personalized medicine approach with integration of clinical nomograms and genomics to better predict which patients require treatment and when.
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