- Pancreatic necrosis complicates approximately 20% of cases of acute pancreatitis. Traditional treatment has been surgical débridement or percutaneous drainage. Necrotic tissue can mature to form well-defined, discrete collections of walled-off pancreatic necrosis. Endoscopic ultrasonography (EUS)-guided endoscopic necrosectomy is safe and efficacious and should be considered in symptomatic, infected, or especially large collections. A novel EUS-guided lumen-apposing self-expanding metal stent has been developed to facilitate access and drainage.
Latest Updates


Quality of Life Following Management of Localized Prostate Cancer
- We review specific characteristics of validated instruments measuring health-related quality of life
- Impact of radical prostatectomy, radiation therapy, and brachytherapy on sexual and urinary function
- Quality-of-life following surveillance of men with prostate cancer with either watchful waiting and active surveillance

Endoscopic Techniques for Obtaining Enteral Access
- DPEJ tubes should be considered when percutaneous endoscopic gastrostomy (PEG) tubes are not feasible or are contraindicated.
- Postpyloric feeding (percutaneous gastrostomy with a jejunal extension or direct percutaneous jejunostomy should be considered in severely ill patients (especially those with an APACHE II score over 20).
- In patients with dementia, PEG tube placement does not enhance mortality, prevent aspiration pneumonia, improve nutritional status, or improve quality of life.

- Immunosuppression: its history, current practice and rationale for alternative therapies, side effects, induction versus maintenance
- Transplantation policy evolution, including history of organ sharing, development of national policies, ongoing refinements in allocation practice, ethical considerations
- Living donation, including ethical considerations, workup and selection of potential living donors, surgical technique, risk to donors

- A multidisciplinary team approach in the treatment of peripartum cardiomyopathy is essential in improving maternal outcomes.
- The epidemiologic profile of patients with peripartum cardiomyopathy is complex and multifactorial.
- Aggressive treatment of heart failure is the mainstay of treatment.
- Stabilization of the mother is the priority in the management of peripartum cardiomyopathy in pregnancy.

Evaluation and Treatment of Monogenic Forms of Inflammatory Bowel Diseases
- Advanced genetic platforms have identified more than 50 different monogenic disorders causing inflammatory bowel disease.
- A monogenic cause of inflammatory bowel disease should be suspected in patients with atypical or severe IBD phenotypes.
- The diagnosis of monogenic defects is made through a combination of functional immunologic studies and DNA sequencing (whole exome sequencing).
- Monogenic IBDs usually present in the first years of life, but several diseases manifest adolescence or adulthood.
- Identifying a monogenic form of inflammatory bowel disease can lead to tailored specific therapy (eg, stem cell transplantation) and have major impact on patient’s care.




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