What's New | Decker

Karthik Giridhar, MD, Manish Kohli, MD

Emphasis on landmark clinical trials in metastatic prostate cancer (especially since 2010)
Critical analysis and summary of PSA-based prostate cancer screening
Advances and integration of genomic sciences in early and advanced stages of prostate cancer

Respiratory system supports metabolism by providing a supply of oxygen and release for carbon dioxide.
Physiologic mechanisms support these respiratory processes along with the balance of body pH, and the understanding of these mechanisms is critical to caring for the critically ill patient.
The above are governed by specific physiologic laws and achieved through unique anatomy described herein.

Respiratory system supports metabolism by providing a supply of oxygen and release for carbon dioxide.
Physiologic mechanisms support these respiratory processes along with the balance of body pH, and the understanding of these mechanisms is critical to caring for the critically ill patient.
The above are governed by specific physiologic laws and achieved through unique anatomy described herein.

Respiratory system supports metabolism by providing a supply of oxygen and release for carbon dioxide.
Physiologic mechanisms support these respiratory processes along with the balance of body pH, and the understanding of these mechanisms is critical to caring for the critically ill patient.
The above are governed by specific physiologic laws and achieved through unique anatomy described herein.

Respiratory system supports metabolism by providing a supply of oxygen and release for carbon dioxide.
Physiologic mechanisms support these respiratory processes along with the balance of body pH, and the understanding of these mechanisms is critical to caring for the critically ill patient.
The above are governed by specific physiologic laws and achieved through unique anatomy described herein.

Population-based incidence breast cancer in young women have been stable.,
Growth of this population demographic has resulted in larger numbers of young patients.
Young women are more likely to be diagnosed with aggressive phenotypes, but systemic therapies improved outcomes.
Options for locoregional and systemic therapy should be based on disease stage phenotype.
Genetic counseling and fertility preservation options should be discussed with all young breast cancer patients.

Description of current risk stratification and evidence for it used by collaborative groups.
New risk stratification system for high-risk metastatic rhabdomyosarcoma.
Use of PAX3-FKHR/FOXO1 and PAX7-FKHR/FOXO1 fusion-gene status in risk allocation.
Role of [F-18]-fluorodeoxy-D-glucose position emission tomography (FDG-PET) as an emerging imaging modality for the diagnosis, staging, and evaluation of treatment response.

When evaluated by echocardiography, poor scanning windows may lead to underestimation of left ventricular dysfunction compared with evaluation by cardiac MRI in Duchenne muscular dystrophy patients
In performing genetic analysis of malignant hyperthermia cohorts, only 35 RYR1 and 2 CACNA1S of over 200 genetic variants identified are sufficiently characterized to be considered pathogenic for malignant hyperthermia, underscoring the lack of specificity of this testing at present
Next-generation gene sequencing has significantly improved early diagnosis and confirmation of mitochondrial disorders in children

Oncology