Management of Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma
- New International Association of Pancreatology definition of BRPC in 3 domains: anatomic, biological, and conditional.
- Neoadjuvant chemotherapy is preferred in BRPC and may become a standard approach for resectable tumors.
- FOLFIRINOX or gemcitabine/nab-paclitaxel are the two preferred regimens in BPRC and LAPC.
- Due to neoadjuvant chemotherapy, increased number of patients is eligible for resection +/- vein reconstruction.
- PV resection is a safe method for achieving R0 resection in BRPC and highly-selected LAPC.