Latest Updates

Pharmacologic Differences in Children

Raymond Park, MD, Lauren Kelly Ugarte, MA, MD
    • There is increasing focus on the impact of anesthetic medication effects on the developing brain with a goal to improve patient safety.
    • Dexmedetomidine is one particular medication found to confer protection to the developing brain in the anesthesia setting and will likely have increasing clinical applications for the pediatric anesthesiologist.
    • Technology and innovative engineering have led to the development and application of tools to improve pediatric patient compliance with anesthesia-related procedures such as needleless medication delivery systems to aid in painless IV placement and the use of small electronics as distraction for mask induction.

Coronaviruses: HCoV, SARS-CoV, MERS-CoV, and COVID-19

    • Specific features on high resolution CT imaging for the more severe coronavirus syndromes are now accepted for clinical diagnosis in the appropriate context, followed by RT-PCR confirmation. This includes ground-glass opacity, with lower-lobe and bilateral involvement, and septal thickening. Other characteristics make diagnosis more or less likely.
    • Molecular studies of the evolution of the S protein affinity for COVID-19 allow more complete understanding of the mechanism of transmission and predisposing factors. These attachment proteins have highest affinity for ACE2 receptors on type II pneumocytes. What remains to be explained is the presence of virus in saliva, blood, urine and gastrointestinal tract: Are these potential modes of transmission?
    • Two clinical trials have demonstrated promise for SARS-CoV-2 immunization; humoral and cellular immune responses are elicited. The preliminary data of these studies were published on July 20, 2020.

Sympathetic Blocks

Shafik Boyaji, MD, Christopher J. Gilligan, MD
    • The use of ultrasound has increased in recent years due to improved safety and efficacy.
    • The use of sympathetic blocks to treat refractory cardiovascular pathology.
    • Better understanding of sympathetically mediated pain.

Clinical Management of Drug Use Disorders

Timothy Ando, MD, James Jackson, MD, Alexander Thompson, MD, MBA, MPH
    • Outlines updated DSM-5 classifications of substance use disorders
    • Synthesizes current heritable and genetic factors in substance use disorders
    • Reviews current treatment options with the strongest evidence base
    • Updated with 2020 ASAM Practice Guidelines: Opioid Use Disorder

Pelvic Organ Prolapse IV: Surgical Options

Veronica Demtchouk, MD, Peter Rosenblatt, MD
    • Minimally invasive approaches to traditional open abdominal sacrocolpopexy result in decreased patient morbidity and faster recovery while providing similar anatomic and subjective outcomes
    • Uterine-sparing hysteropexy procedures eliminate complications attributed to hysterectomy at the time of prolapse repair while providing similar anatomic and subjective outcomes
    • Numerous native tissue repair techniques allow for prolapse repair without the use of synthetic graft material

Neurobiology of Addiction

Alex Gogliettino, Program in Neuroscience, Marc Potenza, MD, PhD, Sarah Yip, MSc, PhD, Yasmin Zakiniaeiz, MSc, Zu Wei Zhai, PhD
    • Epidemiology of and heritable risk factors for developing addictive disorders
    • Dysregulated brain networks and neurochemical systems in several substance and nonsubstance addictions
    • Treatment options for substance and nonsubstance addictions
    • Updated with 2020 ASAM Practice Guidelines: Opioid Use Disorders

Clinical Management of Drug Use Disorders

Timothy Ando, MD, James Jackson, MD, Alexander Thompson, MD, MBA, MPH
    • Outlines updated DSM-5 classifications of substance use disorders
    • Synthesizes current heritable and genetic factors in substance use disorders
    • Reviews current treatment options with the strongest evidence base
    • Updated with 2020 ASAM Practice Guidelines: Opioid Use Disorder

Clinical Management of Drug Use Disorders

Timothy Ando, MD, James Jackson, MD, Alexander Thompson, MD, MBA, MPH
    • Outlines updated DSM-5 classifications of substance use disorders
    • Synthesizes current heritable and genetic factors in substance use disorders
    • Reviews current treatment options with the strongest evidence base
    • Updated with 2020 ASAM Practice Guidelines: Opioid Use Disorder
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