Preterm Premature Rupture of Membranes
- In the setting of preterm premature rupture of membranes, pregnancy outcome is contingent upon the underlying cause, gestational age at diagnosis and delivery, and presence of complications (placental abruption, infection).
- Latency (time from rupture of membranes to delivery) depends on gestational age, severity of oligohydramnios, number of fetuses (shorter in twins), presence or absence of complications, fetal wellbeing, and use of broad-spectrum antibiotics.
- Efforts to reseal ruptured membranes using a variety of tissue sealants has been attempted, but neither the safety nor efficacy of these sealants has yet been established.






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