- The use of buprenorphine to treat opioid dependence and pain
- Epidemiology on prescription drug abuse
- Comprehensive risk mitigation and exit strategies for pain practitioners using opioids to manage pain
Latest Updates
- Randomized controlled trial has shown benefit of topical Tranexamic acid in the control of anterior epistaxis
- Monoclonal antibody treatment is being studied for treatment of chronic sinusitis
- Systematic review of adjunct steroid use in peri-tonsillar abscess shows this treatment may result in more rapid recovery
- Research suggests dexamethasone therapy and/or budesonide aerosols may reduce airway obstruction in epiglottitis
- Recent seasonal influenza epidemics have shown that acute parotitis is associated with acute influenza A infection
- Randomized controlled trial has shown benefit of topical Tranexamic acid in the control of anterior epistaxis
- Monoclonal antibody treatment is being studied for treatment of chronic sinusitis
- Systematic review of adjunct steroid use in peri-tonsillar abscess shows this treatment may result in more rapid recovery
- Research suggests dexamethasone therapy and/or budesonide aerosols may reduce airway obstruction in epiglottitis
- Recent seasonal influenza epidemics have shown that acute parotitis is associated with acute influenza A infection
- Randomized controlled trial has shown benefit of topical Tranexamic acid in the control of anterior epistaxis
- Monoclonal antibody treatment is being studied for treatment of chronic sinusitis
- Systematic review of adjunct steroid use in peri-tonsillar abscess shows this treatment may result in more rapid recovery
- Research suggests dexamethasone therapy and/or budesonide aerosols may reduce airway obstruction in epiglottitis
- Recent seasonal influenza epidemics have shown that acute parotitis is associated with acute influenza A infection
Management of Neuroendocrine Tumors of the Pancreas
- Endonucleation and minimally invasive techniques are continually investigated for management in subsets of PNETs, providing lower incidence of complications, shorter operative time, and faster recovery.
- Gene expression biomarkers can be employed for prognostication, possibly playing a role in determining approach to management. For instance, ARX/PDX1, ATRX/DAXX and ALT genes show prognostic value in NF PNETS, including those smaller than 2 cm.
- Recent evidence suggests that more aggressive indication for surgery may be necessary for certain subets of PNET between 1 cm to 2 cm. Up to 11% of NF PNETs exhibit distant metastasis, suggesting that watchful waiting and follow-up are not optimal approaches to these patients.
Management of Neuroendocrine Tumors of the Pancreas
- Endonucleation and minimally invasive techniques are continually investigated for management in subsets of PNETs, providing lower incidence of complications, shorter operative time, and faster recovery.
- Gene expression biomarkers can be employed for prognostication, possibly playing a role in determining approach to management. For instance, ARX/PDX1, ATRX/DAXX and ALT genes show prognostic value in NF PNETS, including those smaller than 2 cm.
- Recent evidence suggests that more aggressive indication for surgery may be necessary for certain subets of PNET between 1 cm to 2 cm. Up to 11% of NF PNETs exhibit distant metastasis, suggesting that watchful waiting and follow-up are not optimal approaches to these patients.
- Cannabis induces differential effects on energy homeostasis in the context of acute vs. chronic use; acute use stimulates energy intake
- Chronic use dampens endogenous eCB tone, decreasing energy storage
- Epidemiologic data demonstrate that chronic cannabis users tend to have lower BMIs with lower prevalence of obesity compared to nonusers
- Full CB1 antagonists (rimonabant) induce weight loss in obese patients, but are associated with psychiatric adverse effects
- Partial agonist/antagonist agents, such as THCV, may solve blockade of eCB tone responsible for increased energy intake, while avoiding adverse effects
- Recreational cannabis use may be associated with development and progression of certain cancer cell types (eg, hepatocellular carcinoma, prostate cancer, testicular germ cell tumor)
- Cannabis has shown antineoplastic effect in halting progression of certain cancer types and inducing apoptosis of cancer cell lines
- Research to delineate the role of cannabinoid therapy is hampered by legislative hurdles (ie, schedule I agent)
- Cannabis use may have application in palliation of physiologic states brought on directly by cancer (cachexia) or indirectly by chemotherapy-induced effects ( nausea, neuropathic pain, cardiomyopathy)
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