Latest Updates

Cardiac Support Devices

    • Intra-aortic balloon counterpulsation in cardiac surgery
    • Short-term percutaneous and surgically placed devices for circulatory support
    • Long-term continuous-flow left ventricular assist devices in the treatment of chronic heart failure
    • Extracorporeal membrane oxygenation (ECMO) for the treatment of acute heart failure and cardiogenic shock
    • ECMO applications in the setting of advanced cardiac life support, or extracorporeal life support

Cardiac Support Devices

    • Intra-aortic balloon counterpulsation in cardiac surgery
    • Short-term percutaneous and surgically placed devices for circulatory support
    • Long-term continuous-flow left ventricular assist devices in the treatment of chronic heart failure
    • Extracorporeal membrane oxygenation (ECMO) for the treatment of acute heart failure and cardiogenic shock
    • ECMO applications in the setting of advanced cardiac life support, or extracorporeal life support

Deep Vein Thrombosis and Venous Thromboembolism in the Critically Ill

    • Point-of-care ultrasonography for bedside diagnosis of deep vein thrombosis and pulmonary embolism
    • Evidence-based guidelines for deep vein thrombosis prophylaxis among trauma patients
    • Recommendations for therapeutic anticoagulation, including a discussion of non–vitamin K oral anticoagulation agents 

Thoracic Outlet Syndrome

    • TOS is divided into three distinct subtypes: neurogenic, venous, and arterial. Symptoms are produced relative to which of the neurovascular structures is compressed in the thoracic outlet.
    • Recent data on long-term results after thoracic outlet decompression for neurogenic thoracic outlet syndrome
    • New video of transaxillary first rib resection and anterior scalenectomy from the surgeon’s perspective 

Molecular Genetics of Cancer

    • In the United States, an estimated 14.5 million Americans had a history of cancer as of January 1, 2014, with the most common types being prostate, breast, and colon and rectal cancers… Recent studies have indicated that metastases may remain in a latent or dormant state in the body… The DASatinib versus Imatinib Study In Treatment-Naïve Chronic Myelogenous Leukemia (CML) patients (DASISION) study, a randomized, phase III clinical trial comparing dasatinib versus imatinib therapy in patients with chronic-phase CML, demonstrated a deeper response and an improved 3-year progression-free overall survival in patients on dasatinib therapy compared with imatinib.

Thoracic Outlet Syndrome

    • TOS is divided into three distinct subtypes: neurogenic, venous, and arterial. Symptoms are produced relative to which of the neurovascular structures is compressed in the thoracic outlet.
    • Recent data on long-term results after thoracic outlet decompression for neurogenic thoracic outlet syndrome
    • New video of transaxillary first rib resection and anterior scalenectomy from the surgeon’s perspective 

Steroid Replacement in Critical Care

    • The relative contribution of genomic and nongenomic mechanisms to corticosteroids’ therapeutic effects varies with the dose administered; the higher the dose, the greater the contribution of nongenomic effects.
    • Steroid replacement may be associated with survival benefit in adults with sepsis or septic shock, acute respiratory distress syndrome, or community-acquired pneumonia.
    • In sepsis, corticosteroids are best administered within the first 24 hours of management and for at least 3 days at full dose.

Central Nervous System Infections

    • Serogroup B meningococcal vaccines. The incidence of community-acquired bacterial meningitis has declined over the past 30 years, in part due to the advancement and implementation of vaccination programs (Haemophilus influenzae type b [1987], Streptococcus pneumoniae or pneumococcal [2000], and Neisseria meningitidis or meningococcal [2005] vaccines) in the United States and western Europe
    • Use of steroids for bacterial meningitis. In patients with bacterial meningitis, dexamethasone delivered prior to (or simultaneously with) the initial empirical antibiotics and continued 4 days thereafter was associated with a significant reduction in the composite end point of death or significant neurologic disability and death at the 2-month follow-up compared with placebo
    • Development of molecular diagnostics (e.g., 16S polymerase chain reaction [PCR]) for identifying pathogens. Broad-range bacterial PCR amplifies species-specific gene coding for 16S ribosomal RNA of common pathogens; the sensitivity depending on the pathogen is 61 to 88% with specificities greater than 95%
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