- Until recently, it was thought that chromosomal translocations are very uncommon in carcinomas occurring in adults. However, a series of studies have now demonstrated that the majority of prostate carcinomas harbor translocations between genes encoding one of two ETS-related transcription factors, ERG or ETV1, and the androgen-regulated gene TMPRSS2.
- Exposure to ionizing radiation is another cause of cancer linked directly to genetic damage. The incidence of leukemias and various solid tumors in atomic bomb survivors provided data for classic studies of radiation dosage and its consequences. More recent data derive from cancer cases arising as a late complication of radiation therapy or radiomimetic chemotherapy used for treatment of an initial malignancy.
- In addition to general metastasis promoters, recent studies have begun to uncover factors that mediate metastasis to specific organs such as lung and bone. A critical property required for the growth of cancers beyond a minimal size is the recruitment of blood vessel.
Latest Updates
- Intra-aortic balloon counterpulsation in cardiac surgery
- Short-term percutaneous and surgically placed devices for circulatory support
- Long-term continuous-flow left ventricular assist devices in the treatment of chronic heart failure
- Extracorporeal membrane oxygenation (ECMO) for the treatment of acute heart failure and cardiogenic shock
- ECMO applications in the setting of advanced cardiac life support, or extracorporeal life support
Acute Kidney Injury in Critically Ill Patients
- Sepsis as a prevalent syndrome and precipitant for AKI in the surgical ICU population
- Biomarkers as tool to facilitate early diagnosis of AKI
- AKI severity and duration as determinants of poor long-term outcome
- AKI severity as stratification tool for those that may benefit from closer monitoring
- Intra-aortic balloon counterpulsation in cardiac surgery
- Short-term percutaneous and surgically placed devices for circulatory support
- Long-term continuous-flow left ventricular assist devices in the treatment of chronic heart failure
- Extracorporeal membrane oxygenation (ECMO) for the treatment of acute heart failure and cardiogenic shock
- ECMO applications in the setting of advanced cardiac life support, or extracorporeal life support
Acute Kidney Injury in Critically Ill Patients
- Sepsis as a prevalent syndrome and precipitant for AKI in the surgical ICU population
- Biomarkers as tool to facilitate early diagnosis of AKI
- AKI severity and duration as determinants of poor long-term outcome
- AKI severity as stratification tool for those that may benefit from closer monitoring
- Intra-aortic balloon counterpulsation in cardiac surgery
- Short-term percutaneous and surgically placed devices for circulatory support
- Long-term continuous-flow left ventricular assist devices in the treatment of chronic heart failure
- Extracorporeal membrane oxygenation (ECMO) for the treatment of acute heart failure and cardiogenic shock
- ECMO applications in the setting of advanced cardiac life support, or extracorporeal life support
- In the United States, an estimated 14.5 million Americans had a history of cancer as of January 1, 2014, with the most common types being prostate, breast, and colon and rectal cancers… Recent studies have indicated that metastases may remain in a latent or dormant state in the body… The DASatinib versus Imatinib Study In Treatment-Naïve Chronic Myelogenous Leukemia (CML) patients (DASISION) study, a randomized, phase III clinical trial comparing dasatinib versus imatinib therapy in patients with chronic-phase CML, demonstrated a deeper response and an improved 3-year progression-free overall survival in patients on dasatinib therapy compared with imatinib.
- TOS is divided into three distinct subtypes: neurogenic, venous, and arterial. Symptoms are produced relative to which of the neurovascular structures is compressed in the thoracic outlet.
- Recent data on long-term results after thoracic outlet decompression for neurogenic thoracic outlet syndrome
- New video of transaxillary first rib resection and anterior scalenectomy from the surgeon’s perspective
.png)
