Latest Updates

Stroke and Other Cerebrovascular Diseases

Scott E. Kasner, MD, MSCE, FAHA, FAAN, Christina A Wilson, MD, PhD
    • Recent advances in endovascular therapy for acute ischemic stroke
    • Updated guidelines for administration of intravenous recombinant tissue plasminogen activator
    • Recent advances in antithrombotic choice for directed secondary stroke prevention
    • Current recommendations for the management of acute ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage

Seronegative Spondyloarthritis: Epidemiology, Pathogenesis, And Pathology

Walter P Maksymowych, MB, ChB, FRCP (UK), FRCPC, FACP
    • Disease association with the IL23R gene and the key role of IL-23 in the activation and expansion of a distinct phenotype of T helper (Th) cell characterized by expression of IL-17, the Th17 cell, represents a major advance in our understanding of spondyloarthritis.
    • Increasing evidence supports a role for innate lymphoid cells (ICLs) in the pathogenesis of spondyloarthritis, especially group 3 ILCs that produce IL‑17 and IL‑22.
    • New genetic associations have been described with three new aminopeptidases (ERAP2, LNPEPP, and NPEPPS), protective variants having reduced rates of peptide cleavage, thereby changing both the length and amino acid composition of peptides available for binding to B27.  

Neurologic Diseases in Pregnancy 

Emily L Johnson, MD, Peter W Kaplan, MBBS
    • Lamotrigine and levetiracetam are preferred in pregnancy, while valproate should be avoided.
    • Tissue plasminogen activator (tPA) should be considered in pregnant women with potentially disabling strokes.
    • Noncontrast magnetic resonance imaging is safe for use in pregnancy.

Understanding Patient Safety in Surgical Care

Amir Ghaferi, MD, MS, FACS
    • The widespread adoption of a systems-based approach to surgical patient safety across healthcare systems
    • Public reporting and ongoing critical evaluation of surgical quality measures with an emphasis on ensuring surgeons are more aware of these measures and their implications
    • Increased emphasis on the education of future surgeons and healthcare leaders on quality measurement and evaluation has resulted in significant gains in the understanding of surgical safety

Understanding Patient Safety in Surgical Care

Amir Ghaferi, MD, MS, FACS
    • The widespread adoption of a systems-based approach to surgical patient safety across healthcare systems
    • Public reporting and ongoing critical evaluation of surgical quality measures with an emphasis on ensuring surgeons are more aware of these measures and their implications
    • Increased emphasis on the education of future surgeons and healthcare leaders on quality measurement and evaluation has resulted in significant gains in the understanding of surgical safety

Understanding Patient Safety in Surgical Care

Amir Ghaferi, MD, MS, FACS
    • The widespread adoption of a systems-based approach to surgical patient safety across healthcare systems
    • Public reporting and ongoing critical evaluation of surgical quality measures with an emphasis on ensuring surgeons are more aware of these measures and their implications
    • Increased emphasis on the education of future surgeons and healthcare leaders on quality measurement and evaluation has resulted in significant gains in the understanding of surgical safety

Epidemiology of Male Infertility 

Omer A Raheem, MD, Thomas J Walsh, MD
    • Male infertility is not a reportable disease.
    • Frequently, the empiric treatment of male factor infertility involves assisted reproductive technology (in vitro fertilization) that primarily treats the female partner.
    • Male infertility is variable with a multitude of influencing factors (racial variation, geographical variation, at-risk groups, and associated conditions including medical and environmental factors) that are of the utmost importance to a larger audience of clinicians from varying specialties.

Epidemiology of Male Infertility 

Omer A Raheem, MD, Thomas J Walsh, MD
    • Male infertility is not a reportable disease.
    • Frequently, the empiric treatment of male factor infertility involves assisted reproductive technology (in vitro fertilization) that primarily treats the female partner.
    • Male infertility is variable with a multitude of influencing factors (racial variation, geographical variation, at-risk groups, and associated conditions including medical and environmental factors) that are of the utmost importance to a larger audience of clinicians from varying specialties.
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