• Retrospective studies report a survival benefit for local treatment in metastatic prostate cancer (mPCa) patients.
• First data from a randomized trial does not show a survival benefit for the addition of external beam radiotherapy to androgen deprivation treatment in mPCa.
• Local tumor treatment in patients with mPCa should only be offered within trials.

• Targeting calcitonin gene related peptide can improve migraine pain
• Greater occipital nerve blocks may alleviate migraine acutely
• Clinical decision rules can be used to exclude subarachnoid hemorrhage

• Limb-sparing surgery with radiation for extremity soft tissue sarcoma is not inferior to amputation in outcome of disease-specific mortality.
• Completeness of resection (R0, R1, R2) of retroperitoneal soft tissue sarcoma correlates with patient survival.
• Emerging molecular characterization of subtypes of liposarcoma has provided novel therapeutic targets, such as CDK4 inhibitors.

• Provides rapid categorization of the etiology of chronic pelvic pain (CPP) as neurogenic versus nonneurogenic by using an accurate, purposeful physical examination for specific peripheral neuropathies
• Demonstrates the roles of peripheral neuropathies in the etiology of CPP:

1. Pudendal neuropathy as the major source
2. Multiple smaller peripheral neuropathies as associated causes

• Offers a platform for cooperative patient care among end-organ specialists, neurologists, psychologists, pain clinicians, and interventional radiologists
• Highlights successful, sequential treatments that can be immediately adopted by any physician
• Implies that all clinical research studies of CPP should define whether study participants have a peripheral neuropathic basis for their CPP. To date, this has not been done, limiting the value of published study results.

• Non-convulsive status epilepticus is an important cause of coma that requires EEG for diagnosis.
• Basilar artery stroke is a treatable cause of altered mentation
• Physicians should actively seek to identify treatable structural or metabolic causes of coma

• Laparoscopic approach to splenectomy
• Frequent incidental finding with increased use of imaging

• Non-convulsive status epilepticus is an important cause of coma that requires EEG for diagnosis.
• Basilar artery stroke is a treatable cause of altered mentation
• Physicians should actively seek to identify treatable structural or metabolic causes of coma

• Laparoscopic approach to splenectomy
• Frequent incidental finding with increased use of imaging